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The lack of significant demyelination observed with 3 weeks administration of cuprizone powder may reflect delayed cuprizone intake, rather than a complete lack of efficacy, given the significant loss of mature ASPA+ oligodendrocytes seen in this group

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An alternative strategy of starting the diagnostic investigation with mRNA sequencing has also been recommended, particularly because of the delay in diagnosis that can occur when glutathione synthetase deficiency results from a splice site mutation (02)

And, they can walk extended distances with the addition of cane or something to lean on