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Its unique mechanism has made it one of the most extensively studied peptides for exploring the biological processes associated with cellular aging and long-term tissue maintenance

Common neurological manifestations include: Paraesthesia (pins and needles) in the hands and feet Numbness and altered sensation Difficulty with balance and coordination (ataxia) Memory problems and cognitive impairment Mood changes, including depression and irritability In severe cases, visual disturbances and confusion These neurological features arise from demyelination of peripheral nerves and the spinal cord, a condition known as subacute combined degeneration when it affects the posterior and lateral columns of the spinal cord

Dutta, D., Pulsipher, A., Luo, W., Mak, H

Although the study involved a large sample size, it is a cross-sectional study and from a single center

These metabolites, particularly bacterial metabolites, play an important role in microbiotahost interactions and influence the immune system and the BM microenvironment