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The first-stage methodology update is a narrow but focused transitional step that limits hospitals to a maximum of four out of five stars (based on at least three Safety of Care measure scores) if they performed in the lowest quartile of the Safety of Care measure group in the 2026 Overall Hospital Quality Star Rating

Analytical work may require sterile water when preservatives could interfere with sensitive detection methods

(Myelination refers to the addition of a fatty sheath surrounding nerve fibers to improve the rate of signal conduction between neurons.) It is also needed to convert the amino acid homocysteine into methionine