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GC cells are typically resistant to ferroptosis due to increased expression of ferritin [4] and glutathione peroxidase 4 (GPX4) [5], which promotes tumor growth and contributes to chemoresistance

Strauch, R

Figure 2 - Scheme of the chemical biotransformation process (Phases I, II and III).Source: Although not a portal of entry, the kidney is an organ where xenobiotics are likely to be concentrated during the excretion process and this may explain the high level of xenobiotic-metabolizing enzymes in this tissue

The ferroptosis catalyst reversed the reducing effect of H 2 O 2 on GSH levels to a certain extent

In this assay, GSH is formed from GSSG by GR