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Higher numbers suggest insulin resistance your cells aren't responding well to insulin, so the pancreas makes more

Endocrinology 139 , 496504 (1998)

Researchers determined the curcumin found in turmeric may help restore adequate levels of glutathione and improve the activity of glutathione enzymes (5)

Indeed, genetic and pharmacological replenishment of NAD + improves the age-related biologic function and increases lifespan at least in worms and mice