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In contrast, the present review adopts a cytokine-centric mechanistic framework, organizing nutraceutical evidence according to their effects on defined inflammatory signaling axes, including NF-B activation, NLRP3 inflammasome signaling, TGF-/SMADmediated fibrogenesis, JAK/STAT pathways, macrophage polarization dynamics, and ferroptosis-associated inflammatory responses across hepatocytes, Kupffer cells, and HSCs

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Discussion In this study, a transcriptomics-based approach was used to examine how YAN concentration impacted H 2 S production and subsequently mRNA levels and gene expression for S