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This side effect can be uncomfortable but is generally not serious if treated promptly

Patients who have initial hemoglobin values of 10 g/dL or less and who are to receive long-term NSAID therapy should have hemoglobin values determined periodically

Additionally, curcumin exhibits significant anti-inflammatory properties by downregulating microglial activation, reducing proinflammatory cytokines, and attenuating TLR4/MyD88/NF-B signaling cascade after TBI (Xie et al., 2014