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Regarding sugar cravings, I find many of the root causes are related to the gut

10.1016/j.biochi.2020.03.015 23 GuoH.LishkoV

Trends Microbiol 13:111118 Averyanov AA, Lapikova VP (1990) Activated oxygen as a possible factor in the autoinhibition of spore germination of the fungus Pyricularia oryzae

In atherosclerosis, macrophages take up OxLDL to form foam cells and orchestrate inflammatory and reparative responses within vascular lesions, thereby playing a pivotal role in plaque formation and progression (28,34,36)