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Equally critical is serines contribution to redox balance through glutathione (GSH) and NADPH generation, which scavenge reactive oxygen species (ROS) and mitigate oxidative stress, a key mechanism of chemotherapy resistance [13, 51, 52]

Expression of TfR1 was increased, while expression of an iron storage protein complex which includes ferritin heavy chain 1 (FTH1) and ferritin light chain (FTL) was decreased during ferroptosis, indicating the increase in iron uptake and decrease in iron storage during this process (Gao et al., 2015)

Shen HR, Wang ZY, Shen Z, Liu TT, Guo YD, Gao TL, et al

CrossRef Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL/6J mice Carina Bodden, Sophie Siestrup, Rupert Palme, Sylvia Kaiser, Norbert Sachser, S

In practice, approaches cluster into four fronts that span distinct compartments and time scales: Inhibitors of ROS sources NOX (NADPH oxidases): To curb pathological ROS, two complementary strategies are often combined