glutathione peroxidase 1 heme 4: a new player in neurodegeneration? GPX1 - an overview |

Discussion Both l -deprenyl and, to a somewhat lesser extent, clorgyline at a concentration of 1 nM had relatively large radioprotective effects on normal cells and tissues, but did not protect tumour cells to any significant extent

pmid:32863939

Discussion In normal circumstances, intracellular pro-oxidant agents and antioxidant stressors are in a dynamic equilibrium

However, it is less effective for treating retinal conditions, primarily due to rapid clearance of drugs from the ocular surface, non-targeted delivery, and the distance between the ocular surface and retina, contributing to a low drug bioavailability in the posterior segment [41]

Additional factors await identification to shed further light on the role of DNA damage in metabolic homeostasis