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Administration of proteolytic enzymes bromelain and trypsin diminish the number of CD4+ cells and the interferon-gamma response in Peyer's patches and spleen in endotoxemic balb/c mice

Parkin (i.e., Park2) is an E3 ubiquitin ligase that is believed to play an important role in directing misfolded proteins for degradation via the ubiquitin-protease system 74 and helps regulate mitochondrial dynamics through mitochondrial biogenesis, import of mitochondrial proteins and mitophagy (targeting mitochondria to phagosomes) 75

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These findings indicate that FAD synthesis by RFK and FLAD1 is required for FSP1 post-translational stability, with stronger effects consistently observed following depletion of RFK

- Resistance to degradation in the gastrointestinal tract