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Novel pharmacological agents and interventions in myocardial IRI Targeting innate and adaptive immunity: NLRP3-, SGLT- and PARP-inhibitors NLRP3 inhibitors are emerging as a new class of immunomodulatory compounds with potential relevance across multiple inflammatory and cardiometabolic conditions, and their therapeutic potential continues to expand as increasing preclinical and translational evidence clarifies their mechanisms of action

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Here, we investigated the cellular and molecular effects of seladelpar on normal and PBC-like human cholangiocytes

J Viral Hepat 19:353363 Huerga Encabo H, Traveset L, Argilaguet J, Angulo A, Nistal-Villan E, Jaiswal R, Escalante CR, Gekas C, Meyerhans A, Aramburu J, Lopez-Rodriguez C (2020) The transcription factor NFAT5 limits infection-induced type I interferon responses

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