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Pharmacokinetic analysis showed a significant reduction in both the maximum serum concentration (Cmax) and area under the curve (AUC) for acetaldehyde in the GSH group, further confirming the efficacy of GSH in accelerating acetaldehyde clearance from the bloodstream

The researchers also found that the cell deaths were promoted by addition of Fe, while inhibited by antioxidants (ferrostatin and Vitamin E) and iron chelator ciclopirox olamine [277]

This polypharmacological approach stands in contrast to conventional chemotherapeutics, which typically target single molecules and are therefore more susceptible to resistance development (Liao et al., 2023)

The current study has several limitations that need to be addressed in future research

NAD+ IV infusions deliver a higher dose slowly over time and are often chosen for more comprehensive cellular support