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The results from this study may reveal an important basis underlying the gender-associated differences in the longevity and the susceptibility to certain age-related diseases, and also further suggest that the decreased synthesis, which is mainly due to the down regulation of GCL gene expression, may be responsible for the age-associated decline in GSH content

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Persistent ER stress and UPR failure can lead to apoptosis and activation of inflammatory pathways like NF-B and MAPK, increasing pro-inflammatory cytokine production (72)

10.1523/JNEUROSCI.4062-12.2013 41 MelisM.CarboniE.CaboniP.AcquasE

Glutaminase inhibitors, for instance, have been shown to decrease tumor burden