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The significant increase of Cu level will promote the catalytic effect of copper-mediated in mitochondria, resulting in the generation of reactive oxygen species (ROS), and excessive ROS will lead to the oxidation of the amino acid side chain of the protein or the break of the peptide chain, which will change the properties of the protein and lead to the loss of various enzyme activities

H(2)O(2) and ethanol act synergistically to gate ryanodine receptor/calcium-release channel

doi: 10.1016/j.redox.2024.103369, 123 WangH.WuS.JiangX.LiW.LiQ.SunH.et al

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L-Carnitine and acetyl-l-carnitine roles and neuroprotection in developing brain