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The oxidation of the dihydrolipoyl moiety is catalyzed by a dihydrolipoamide dehydrogenase ( Figure 2 )

Although this rapid desensitization phenomenon appears paradoxical to the rewarding mechanism, it effectively enhances the signal-to-noise ratio of dynamic rewarding signals by reducing background dopamine noise, thereby strengthening the coupling between nicotine rewarding and environmental cues (Rice and Cragg, 2004

[...] He's always trying to do his best: aim higher, move forward"

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10.1016/j.jpeds.2016.08.095 [DOI] [PubMed] [Google Scholar] 17.Prakash C, Clouse RE