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A small impurity or a peptide synthesized with an incorrect amino acid sequence in one vial is a problem

Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A

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Biochemically, LCD proceeds upon LMP when cells are exposed to various lysosomotropic detergents (e.g., lipid metabolites (phosphatidic acid, sphingosine), ROS), including cathepsins [178,179,180,181] (Fig

This points to a P2X 7 R-mediated mechanism, in which [Ca 2+ ]i levels may promote GABA release through reversal of the GAT transporter activity ( GSH induces [Ca 2+ ]i transients and GABA release through glial P2X 7 R Previous data have shown that activation of P2X 7 R in rat hippocampal slices leads to GABA release