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In AT, obesity induces pronounced ER stress that fundamentally disrupts metabolic homeostasis through multiple tissue-specific mechanisms (80, 98)

[21] [22] To be specific, molecular O 2 is reduced to O 2 (a ROS called superoxide) when it absorbs an excited electron released from compounds of the electron transport chain

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Further investigation is needed to better understand how the combination of oxygen and mechanical stretch intersect in the developing lung and what the long-term ramifications are for preterm infants exposed to these necessary and common therapies