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Previous studies have shown that mutation or inactivation of GPX4 can trigger ferroptosis so it is believed that the enzyme plays a key role in the process of ferroptosis (Yang et al., 2014

Byron Bitanihirwe for his excellent assistance with the preparation of the manuscript, Morgane Baumgartner, Adeline Cottier and Gloria Reuteler for their helpful technical assistance, and Dr Fulvio Magara and the technical staff of the Centre dEtudes du Comportement (Center for Psychiatric Neuroscience, CHUV) for their support in animal facilities

152 ZhangY.HuangL.ZhangJ

Researchers have been studying Nicotinamide Adenine Dinucleotide (NAD+), a derivative of the enzyme niacin for decades

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