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As peptide ingredients, their formulation may encounter some challenges, mainly due to their hydrophilic (high aqueous solubility and low partition coefficient) and unstable nature

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Topical concentrations reported in studies and commercial formulations vary, typically ranging from 0.1% to 5% and applied once or twice daily, and represent the best-supported evidence base [2]

In melanocytes, NAM functions as a potent antioxidant that protects cells from oxidative stress, ultraviolet (UV) irradiation, and senescence