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doi: 10.1155/2021/9947370 82 MartineauARCatesCJUrashimaMJensenMGriffithsAPNurmatovUet al

The term 'synergy' gets used when two compounds produce slightly better results together than alonebut true synergy means the combined effect exceeds the sum of individual effects, and that requires targeting rate-limiting steps in a shared pathway

In epilepsy, this interplay is evident in models such as the lithium-pilocarpine (Li-Pilo) model of SE, which recapitulates key features of epileptogenesis including altered glucose metabolism (Dank et al., 2022) and mitochondrial bioenergetics with increased markers of oxidative damage (Carrasco-Pozo et al., 2015

It is also important to consult with a healthcare provider before starting B12 shots, especially for those on medications that may interfere with B12 absorption or metabolism

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