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Similar to previously reported results [3] no maturation cleavage of CAV20 VP0 to VP2 and VP4 could be observed in cells depleted of GSH (Figure 5A, compare lanes 1 and 2), an observation indicating that no infectious particles were formed

Moreover, addition of DEM, a potent thiol-depleting agent, in cell cultures led to I B degradation in TNF- -treated hGH-producing cells (Figure 4D, lower right), while, as expected, a pattern of stabilised I B was shown in U937-hGH cells with an unmodified thiol level (Figure 4D, upper right)

10.1111/j.1365-2036.2010.04347.x

Previous studies have shown that the microbiota influences Th17 response in the gut [70], and that this intestinal inflammation can enhance pathogen colonization [71]