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Studies have shown that ORAOV1 increases the intracellular proline concentration and subsequently reduces ROS production by binding to pyrrolin-5-carboxylate reductase (PYCR) in esophageal squamous cell cancer (ESCC), thereby increasing tumorigenicity and tumor growth [174]

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This combined approach allows researchers to examine potential synergistic effects beyond single-pathway activation

Oncogene 23: 51315137 [DOI] [PubMed] [Google Scholar] Cooper C.S., Park M., Blair D.G., Tainsky M.A., Huebner K., Croce C.M., et al

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