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Finally, through an extensive literature review of relevant toxicological studies in rats covering numerous chemicals, we address three crucial questions that remain to be answered in order to ensure the optimal use of NR assessment in a regulatory context: 1 ) Do different chemical classes have different modes of action when affecting NR and if so, how does this relate to their effects on AGD

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Rudofsky G, Amadid H, Braae UC, et al

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