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In a study of betaine reduction of Hcy, low dose additional supplementation with betaine anhydrous of 500-3000 mg/day lowered Hcy levels in healthy subjects, with a small further drop at 6000 mg/day [227]

Front Pharmacol 5:192 Lam LK, Zhang Z, Board PG, Xun L (2012) Reduction of benzoquinones to hydroquinones via spontaneous reaction with glutathione and enzymatic reaction by S -glutathionyl-hydroquinone reductases

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That gap is where TB-500 and GHK-Cu become critical inside the GLOW protocol