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spectra obtained from cystic wall (b) show a minor peak of lactate and almost normal profile of major brain metabolites (which is not typical for glioblastoma)

9 The role of ECM in the development of metastases Tumor cells need to acquire several specific properties to metastasize, including increased motility, invasiveness, plasticity, and the ability to modulate and colonize distant metastatic sites while altering the local microenvironment (Figures 5, 6)

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