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Inhibition of the mPTP and lipid peroxidation is additively protective against I/R injury

Compared to mice given free GSH, whey encapsulated GSH resulted in significantly increased antioxidant capacity in the plasma through the entire period of study (from 15 minutes until 240 minutes after ingestion).* Non-toxic In the 28-day toxicology arm of the study, a diet containing up to 4% GSH in a whey protein matrix was found to be safe and non-toxic

FOXO1, a pro-apoptotic transcription factor in cartilage, was investigated and it was found that silencing of FOXO1 in chondrocytes resulted in a significant reduction in the mRNA levels of pro-apoptotic genes caspase-3, caspase-8, caspase-9 and TRAIL

While TAU's affinity for isolated lysosomes may not be perfectly tailored for CMA substrate interaction, truncated TAU mutants do not completely translocate into the lysosomal lumen for degradation, despite the existence of two CMA targeting motifs in TAU C-terminal region (179)