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Description

Two pairs of conserved cysteines are required for the oxidative activity of Ero1p in protein disulfide bond formation in the endoplasmic reticulum

Despite this, there are no existing therapies for type 2 diabetes, metabolic disease, or insulin resistance that specifically target GLUT4

control = DMEM D1145 media treated monolayers

Moreover, oral treatment with NADPH oxidase antagonists mitigates the clinical and pathological features of parkinsonism in the MPTP marmoset model (Philippens et al., 2013)