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In the search for more effective medication treatments for PD, the overriding question that connects all of these models is as follows: how accurately do they recapitulate the human situation, and how predictive are they of the successful translation of pharmaceuticals into the clinic

J Inherit.Metab Dis 2008;31 Suppl 2:S219-S222

This impairment can cause additional issues such as increased susceptibility to infection or disease and reduced vaccine efficacy

Rifabutin act as a weaker inducer than RIF, with 23 times lower effect on CYP3A4, making drug interactions less impactful in clinical practice (AIFA - Ricerca Farmaco, 2024)

nigrum extract [5]