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The endogenous activation of the Nrf2-ARE system during the development of pathology in the SOD1 G93A mouse model of ALS showed that the early Nrf2-ARE activation occurs in muscle tissue and that eventually, it progresses in a retrograde manner leading to MN loss [58], as previously described

into inflammation-induced neurodegeneration during MS at the Institute of Neuroimmunology and Multiple Sclerosis is supported by the Bundesministerium fr Bildung und Forschung (16GW0308K), Deutsche Forschungsgemeinschaft (FR1720/25-1, FR1720/24-1, FR1720/11-2, FR1720/9-2, SFB1328 A16), Gemeinntzige Hertie-Stiftung (P1200091, P1210014, P1220064, P1230093), Deutsche Multiple Sklerose Gesellschaft (V6.2), Werner Otto-Stiftung (07/100), Walter und Ilse Rose-Stiftung (T0298/38958/2021) and Research Funds of the University Medical Center Hamburg-Eppendorf

Thus, antioxidants could expose these cells to reductive stress, which is also associated with cellular dysfunctionality 114,115