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As an antioxidant, NAD+ is the active form, and NADH is inactive but can be regenerated for use within cells

Therefore, targeting the HIF1-c-MYC-PGC1 pathway enhances thermogenesis in beige adipose tissue, thereby providing a potential therapeutic strategy to mitigate obesity and metabolic disorders associated with high-fat diets [142]

Recently, the CAS phenotype has increasingly been associated with commonly occurring neurodevelopmental comorbidities, including motor and cognitive impairments, attention deficit hyperactivity disorder, seizures and autism spectrum disorders [8,9,10]

& Gopal, S

J Biol Chem 280:2271522720