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Allow me to explain the reasons why: 1

It is also independently associated with abnormal lipid metabolism as well as an increased risk of cardiovascular and cerebrovascular disease compared to E3 and E2 alleles (Belloy et al., 2019

This leads to alterations in substrate utilization and energy metabolism

However, kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), impose a substantial burden on global healthcare systems due to their high mortality rates and the limited treatment options ( In recent years, the role of post-translation modification (PTM) in renal diseases has received widespread attention