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Ligand-interactions with several immune cell surface receptors have been shown to induce controlled fluxes in ROS through the activation of NOX family enzymes as well as mitochondrial enzymes (complexes I and III of the electron transport chain)

(126) reported that catecholaminergic (CA) neurons in the ventrolateral medulla (VLM) of mice were activated during fasting and demonstrated that the activity of these CA neurons influenced T cell distribution in EAE

Smirnova GV, Oktyabrsky ON

These scenarios have several important implications, as they not only increase risk for later persistent symptoms but they may also set patients on a clinical trajectory that never resembles the classic, textbook manifestations of Lyme disease

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