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Smoking fosters an environment that promotes the proliferation of specific anaerobic pathogens by compromising blood supply and vasculature, impairing fibroblast function, and inducing a state of heightened inflammation, immune suppression, and oxygen depletion (Palmer et al., 2005)

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The spherical architecture of the MB combined with the cellularly degradable eECM creates a distinct niche that promotes cell viability and maintenance of the secretory acinar cells based on gene and protein expression as well as secretory function based on tissue architecture, gene expression, and secretory agonist-responsive calcium signaling 17