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Further, the therapeutic potential of crocin can be validated through investigations in in vitro models of primary fibroblasts and induced pluripotent stem cells (iPSCs) derived from SCA3 patients, and in vivo models of MJD84.2 transgenic mice harboring a YAC transgene that expresses a human ATXN3 modified with SCA3-associated 84 CAG repeat expansion, and AT3q130 Caenorhabditis elegans expressing full-length ataxin-3 proteins with 130 glutamines

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Other authors reported favourable outcomes with the utilization of RADA16-I self-assembly peptide [206212]

Consistently, the intracellular levels of PDHCs product acetyl-CoA and OGDCs product succinyl-CoA also decreased over time (Fig