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doi: 10.1016/j.jpeds.2014.01.052 127 DichtelLECoreyKEMisdrajiJBredellaMASchorrMOsganianSAet al

Metabolic reprogramming of synovial fibroblasts in osteoarthritis by inhibition of pathologically overexpressed pyruvate dehydrogenase kinases

In SIBO, they often overgrow in the small intestine

BioJOY 90100 BioJOY 30 650 1-2 22-44 /OPITAC 125mg C50mg OPITAC()(C)()() - BioJOYC125mg250mg 3

This intrinsic vulnerability is compounded by a weak copper export system, characterized by low expression of ATP7A/B transporters, which facilitates toxic accumulation [100]