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The absolute deficiency of insulin is the prime reason for T1DM, while T2DM is caused by a variable degree of insulin resistance, impaired insulin secretion, and greater glucose production

The main cytokines involved in MTB infection, mainly include IFN-, IFN-, IL-2, IL-6, IL-10, IL-13, IL-17, TNF-, and chemokines ( Histone deacetylase (HDAC), an important class of enzymes in histone modification, is involved in epigenetic regulatory processes ( Ferroptosis is a regulated necrosis triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage involved multiple infection-immunomodulatory processes ( In macrophages, galectin-8 recognized damaged MTB-containing phagosomes and then targeted MTBs for selective autophagy ( 3.2 NcRNA-related HDT Non-coding RNAs (ncRNAs) account for 98% of total RNAs and are the major RNA transcripts in organisms

Containing the LKKTETQ core motif and surrounding sequence

To determine if the administered treatment presents toxic effects on normal cells, we cultured rat neural stem cells (NSCs) to simulate 3D culture conditions in normal neurospheres (Fig