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On the basis of impaired cushioning function, especially of large arteries, arterial stiffness causes (i) ISH, (ii) reduced coronary perfusion and increased afterload with resulting left ventricular diastolic dysfunction, and (iii) microvascular alterations with resulting end-organ damage (e.g., HFpEF, vascular dementia, and chronic kidney disease)

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doi: 10.1007/S00018-022-04380-5/FIGURES/2 199 TavaresRGTascaCISantosCESAlvesLBPorcinculaLOEmanuelliTet al

1 2 3 "Occurrence of 1,4-dioxane in cosmetic raw materials and finished cosmetic products"