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doi: 10.1111/bpa.12426 208 LoisCGonzalezIIzquierdo-GarciaDZurcherNRWilkensPLoggiaMLet al
Thus, these findings underscore the notion that translational mouse models replicate only a subset of human pathology, often readily show therapeutic effects, and lack the complexity of aged human tissues
In contrast, a GSSR intermediate was detected and its decreased steady-state concentration at higher glutaredoxin concentrations was suggested to support monothiol mechanism (i) 60
In mutant SOD1, these aberrant disulfide bonds involve cysteine residues Cys 6 and Cys111, and in both mutant and WT TDP-43, cysteines Cys173, 175, 198, and 244 in the RNA-recognition motif (RRM) are involved (Cohen et al., 2012
