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Vitamin B12 deficiency can lead to blurred vision, making objects appear fuzzy or unclear

These agents in fact reacted adversely with cysteinyl residues in topoisomerase by using mutant yeast TOP2 with all cysteine residues replaced with alanine (cysteineless TOP2)

Iwaoka M, Katakura A, Mishima J et al (2015) Mimicking the lipid peroxidation inhibitory activity of phospholipid hydroperoxide glutathione peroxidase (GPx4) by using fatty acid conjugates of a water-soluble selenolane