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Decreased BDNF levels in the hippocampus lead to an increase in the frequency of depressive behaviors, with fluctuations observed throughout the progression of the disease (Martinowich et al., 2007)

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The decision was based on results from the Phase 3 TROPION-Breast02 trial, which enrolled 644 patients and compared the TROP2-directed antibody-drug conjugate against investigators choice of chemotherapy in the first-line setting

Because effects wear off in 4-6 hours, you can time doses around specific tasks and stop coverage earlier in the evening to protect sleep