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Without water, the chemical reactions that cause degradation, like oxidation, are slowed down almost to a halt, putting the molecule in a highly stable, preserved state

Maslak P, McKenzie S, Scheinberg D, Andreeff M

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One study showed NR at 300 mg/day increased human blood NAD+ ~50% after 8 weeks, whereas higher doses (1000 mg/day) roughly doubled NAD+ levels