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These changes are also related to improvements in quality of life, as they can alleviate common symptoms such as fatigue, jaundice, and gastrointestinal discomfort in patients with advanced liver disease [44]

10.1016/j.cca.2023.117752 85

doi: 10.2741/2109 64 KangYPMockabee-MaciasAJiangCFalzoneAPrieto-FariguaNStoneEet al

However, the cellular stress of the upstream events, i.e., reactive metabolite formation, GSH depletion, and protein adducts formation, is still present and this stress may trigger apoptosis in a limited number of cells (Figure 1)