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Part of the reason could be that arbutin does not form hydrogen bonds with the residues in the C1 region (Table 2).The RMSF values of the residues surrounding Arbutin_c and Arbutin_d were generally low

Jul 2011;164(5):315-340

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At the same time, the patient was started on meningitis therapy (cefotaxime 3 g every six hours, meropenem 2 g every 8 hours, vancomycine 2 g per day, antimycotics - fluconasol 20 mg every six hours, antiswelling treatment 100 mL of 20% mannitol every six hours) and hydrocortisone supplementation (50 mg every eight hours) to prevent presupposed vascular collapse due to secondary adrenal insufficiency

Animal models of depression: are there any