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Conclusion: A second line treatment with BLV+PegIFN can be considered in selected patients and can achieve a virological response in up to 45% of CHD patients with advanced disease and high biochemical and virological activity

Inhibition of Gpx1 induces oxidative stress-induced T-cell hyporesponsiveness and affects Con A-induced T-cell activation and proliferation in human Jurkat T cells Continued ROS exposure induces T-cell hyporesponsiveness through irreversible oxidation

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