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In lung and smoke-exposure models, GHK-Cu was associated with lower pro-inflammatory cytokine readouts and signals consistent with NF-B and p38 MAPK pathway quieting, while Nrf2-linked defenses appeared supported

PMID 15455129)

This is because only a small number of research has been focused on potential toxicological effects in humans, and the great majority of toxicological studies are being carried out in vitro and on animals