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The duration of this study is 18 months with primary endpoints being a significant improvement from baseline in mFARS and significant improvement in ambulation and daily activities being the secondary endpoints ( 5.1.8 RT001 (deuterated fatty acids) PUFAs are susceptible to high rates of oxidation, leading to greater mitochondrial dysfunction (Tamarit et al., 2016)

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Hepatitis delta virus antigens trigger oxidative stress, activate antioxidant Nrf2/ARE pathway, and induce unfolded protein response