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Beyond the Lab: What People Are Experiencing While rigorous human trials are still needed, anecdotal reports and small clinical observations suggest: Waist circumference reduction without significant muscle loss Improved fasting glucose and insulin response Easier recovery from workouts Fewer midday energy crashes A Real-Life Example: Alexs Story Alex had a consistent gym routine and a clean diet, but after turning 40, his midsection became harder to manage

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So over five decades ago Berchtold et al and Tomkin et al, recognise and recommend that metformin users are screened for vitamin B12 deficiency