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Firstly, researchers observed that GHK-Cu increases MMP-2 levels in the conditioned media of cultured dermal fibroblasts, a process not replicated by GHK alone, suggesting that the presence of copper is posited to be necessary for this activity

Site of synthesis and intramitochondrial localization

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A decrease in this ratio indicates increased oxidative stress, potentially triggering stress response programs such as apoptosis, necrosis, or autophagy

a treatment option long considered for many neurodegenerative diseases including Parkinson's disease (PD) has been the application of growth factors with the intention of halting disease progression, restoring lost function, or hopefully both (review, Rangasamy et al., 2010)