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Acknowledgements The authors are thankful to Integral University, Lucknow, and Eras Lucknow Medical College and Hospital, Era University, Lucknow for providing their assistance during this work

Aged fibroblasts in culture, for example display a threefold reduction in population doubling time [34], with older cells reported to have an increased G0/G1 phase proportion due to repression of cell cycle progression genes [35]